Then Katasuke pointed out the difference between Mitsuki and Kawaki, and that is Mitsuki is a full-fledged synthetic clone of Orochimaru and was made scientifically but with organic material. On the other hand, Kawaki isn’t a synthetic human but a normal human being.
But Kawaki’s internal organs have been modified and made up of tech material or artificial materials rather than the organic material, unlike Mitsuki who is made up of organic material. Katasuke did mention that Kawaki is a fabulous work of art and praised the man who had created him. This scientist that has worked on Kawaki seems to be far more superior to both Orochimaru and Katasuke. We have seen in the past that Orochimaru seems to be linked with everything that relates to scientific things. We saw Sasuke immediately pointing out when he encountered Shin Uchiha that Orochimaru will know something about it and it turned out that he was Orochimaru’s creation only.