4. Kaguya Ōtsutsuki
Kaguya Ōtsutsuki was the first wielder of chakra on Earth. She was also known as the Rabbit Goddess, and was feared across the Earth. She had enormous amount of chakra, and she could travel through different dimensions easily.
Since she was the progenitor of chakra, hers was the strongest of all. Kaguya didn’t have Truth Seeking Balls floating around her. However, she was able to produce one that could destroy an entire Universe at will.
3. Toneri Ōtsutsuki
Toneri Ōtsutsuki is the descendant of Hamura Ōtsutsuki himself. He was also able to awaken the Tenseigan after stealing Hanabi Hyuga’s Byakugan. Thanks to the Tenseigan, he could enter the Tenseigan Chakra Mode, which gave him an inconsistent number of Truth Seeking Orbs around him. Using them, he could slide apart the moon, and destroy even the Earth if he wanted to. He was defeated by Naruto Uzumaki despite his immense powers.