4. Kaguya Ōtsutsuki
Kaguya Ōtsutsuki was the first wielder of chakra on earth. She is also known as The Rabbit Goddess. Kaguya Ōtsutsuki has the Kekkei Genkai ability of Byakugan, and Rinne Sharingan. Byakugan gives the user 360° vision, and Rinne Sharingan gives the user the power to use Infinite Tsukuyomi. She also has access to many godly Jutsu via her Byakugan, and Rinne Sharingan.
Mitsuki is a genetically perfect being, made by Orochimaru. It is known that he only has one Kekkei Genkai ability, which is Jūgo clan’s Kekkei Genkai to passively absorb Sage chakra. But, since Mitsuki is genetically perfect it is possible that he has more than one Kekkei Genkai Abilities. I speculate that he has the Wood Release as well.