We’ve seen many Shinobi in Naruto who can use all Five Nature Transformations. Many of them do so via the Rinnegan, or the Sharingan, or via the Six Paths Senjutsu. However, there are a few shinobi who mastered all Five Natures with nothing but hard work.
Here they are —
5. Hashirama Senju
Hashirama Senju was also the First Hokage of the Hidden Leaf Village. He was more commonly known for his Kekkei Genkai, Wood Release. However, Hashirama trained so hard, that he could use all 5 Nature Transformations. He was a really skilled shinobi, and despite his easygoing character, he was a fearsome person when things got serious.