4. Sasuke Uchiha-
Sasuke was the reincarnate of Indra Ōtsutsuki. It was said many times in the series that his chakra was very sinister. A big reason for this was because of him being a reincarnate of Indra. Also, Karin stated that Sasuke’s chakra was very dark, in comparison to Naruto’s bright and warm chakra.
3. Madara Uchiha-
Madara was originally a very nice person but certain consequences caused him to turn rogue. Also, like Sasuke, Madara too was a reincarnate of Indra Ōtsutsuki. Furthermore, Madara was one of the few people who awakened the Mangekyō Sharingan. After that his chakra became more and more sinister.