The Sage of Six Paths is one of the strongest characters in the anime. Also, he was the elder son of Kaguya Ōtsutsuki. After finding out the true nature of her mother, he fought Kaguya alongside his brother. Moreover, he is worshipped by the entire shinobi world. So, today I have made a list of all characters who could possibly defeat him.
6. Sasuke Uchiha-
Sasuke received Six Paths chakra from Hagoromo Ōtsutsuki. He was very intelligent and got used to his new powers quickly. Also, Sasuke could use all the techniques of the Rinnegan fluently. Also, Kurama said that his visual prowess is arguably on the same level the Sage of Six Paths.
5. Naruto Uzumaki-
Naruto received a lot of power ups through the entire series. The biggest one was getting the Six Paths chakra from Hagoromo himself. Also, he had arguably one of the largest chakra reserves in the entire series. Furthermore, his unpredictability makes the life of his opponent(s) very difficult.